Why Some Cells Commit Suicide

Why Some Cells Commit Suicide Apoptosis, or programmed cell death, is a naturally occurring process in the body. It involves a controlled sequence of steps in which cells signal self-termination, in other words, your cells commit suicide.   Apoptosis is a way for the  body to keep checks and balances on the natural  cell division  process of mitosis  or continued cell growth and regeneration. Why Cells Undergo Apoptosis There are several instances in which cells may need to self-destruct. In some situations, cells may need to be removed to ensure proper development. For example, as our brains develop, the body creates millions of more cells than it needs; the ones that do not form synaptic connections can undergo apoptosis so that the remaining cells can function well. Another example is the natural process of menstruation that involves the breakdown and removal of tissue from the uterus. Programmed cell death is necessary to start the process of menstruation. Cells may also become damaged or undergo some type of infection. One way to remove these cells without causing harm to other cells is for your body to initiate apoptosis.  Cells may recognize viruses  and gene mutations and can induce death to prevent the damage from spreading. What Happens During Apoptosis? Apoptosis is a complex process. During apoptosis, a cell triggers a process from within that will allow it to commit suicide. If a cell experiences some type of significant stress, such as DNA damage, then signals are released which cause mitochondria to release apoptosis-inducing proteins. As a result, the cell undergoes a reduction in size as its cellular components and organelles break down and condense. Bubble-shaped balls called blebs appear on the surface of the cell membrane. Once the cell shrinks, it breaks down into smaller fragments called apoptotic bodies and sends out distress signals to the body. These fragments are enclosed in membranes so as not to harm nearby cells. The distress signal is answered by vacuum cleaners known as macrophages. The macrophages clean away the shrunken cells, leaving no trace, so these cells have no chance to cause cellular damage or an inflammatory reaction. Apoptosis can also be triggered externally by chemical substances that bind to specific receptors on the cell surface. This is how white blood cells combat infection and activate apoptosis in infected cells. Apoptosis and Cancer Some types of cancers persist as a result of a cells inability to trigger apoptosis. Tumor viruses change cells by integrating their genetic material with the host cells DNA. Cancer cells are usually a permanent insertion in the genetic material. These viruses  can sometimes initiate the production of proteins that stop apoptosis from occurring. An example of this is seen with papilloma viruses, which have been linked with cervical cancer. Cancer cells that do not develop from viral infection can also produce substances that inhibit apoptosis and promote uncontrolled growth. Radiation and chemical therapies are used as a mode of therapy to induce apoptosis in some types of cancers.

Biography of Brian Cox, Physicist

Biography of Brian Cox, Physicist Physics has had a number of figures who have not only advanced scientists understanding of the universe but also pushed forward a greater understanding of complex scientific questions among the general population. Think of Albert Einstein, Richard Feynman, and Stephen Hawking, all of whom stood out from among the crowd of stereotypical physicists to present physics to the world in their distinctive styles and found an audience of non-scientists for whom their presentations strongly resonated. Though not yet as accomplished as these iconic physicists, British particle physicist Brian Cox certainly fits the profile of the celebrity scientist. He rose to prominence first as a member of British rock bands in the early 1990s before ultimately transitioning to work as an experimental physicist, exploring the cutting edge of particle physics. Though well-respected among physicists, it is his work as an advocate for science communication and education in which he really stands out from the crowd. He is a popular figure in British (and worldwide) media discussing matters of scientific importance, not only in the realm of physics but also more broadly on subjects of public policy and embracing secular principles of rationality. General Information Birthdate: March 3, 1968 Nationality: English Spouse: Gia Milinovich Music Career Brian Cox was a member of the rock band Dare in 1989 until the band split up in 1992. In 1993, he joined the UK rock band D:Ream, which had a number of hits, including the number one Things Can Only Get Better, which went on to be used as a political election anthem in England. D:Ream disbanded in 1997, at which point Cox (who had been studying physics all along and earned his Ph.D.) went on to practicing physics full time. Physics Work Brian Cox received his doctorate in physics from the University of Manchester, completing his thesis in 1998. In 2005, he was awarded a Royal Society University Research Fellowship. He splits his time between work at the University of Manchester and at the CERN facility in Geneva, Switzerland, home of the Large Hadron Collider. Coxs work is on both the ATLAS experiment  and the Compact Muon Solenoid (CMS) experiment. Popularizing Science Brian Cox has not only performed extensive research, but has also worked hard to help popularize science to lay audiences, especially through repeated appearances on the BBC programs such as The Big Bang Machine. In 2014, Brian Cox hosted a BBC Two 5-part television miniseries,  The Human Universe, which explored humanitys place in the universe by exploring the history of our growth as a species and also tackling existential questions such as Why are we here? and What is our future? He also released a book, called  The Human Universe  (co-authored with Andrew Cohen), in 2014. Two of his speeches are available as TED lectures, where he explains the physics being performed (or not being performed) at the Large Hadron Collider. He has co-authored the following books with fellow British physicist Jeff Forshaw: Why Does Emc2 (And Why Do We Care?) (2009)The Quantum Universe (And Why Anything That Can Happen, Does) (2011) He is also a co-host of the popular BBC radio program Infinite Monkey Cage, which is released worldwide as a podcast. In this program, Brian Cox joins with British actor Robin Ince and other guests of renown (and sometimes scientific expertise) to discuss subjects of scientific interest with a comedic twist. Awards and Recognition International Fellow of The Explorers Club, 2002Lord Kelvin prize from the British Association (for his work popularizing science), 2006Institute of Physics Kelvin Prize, 2010Officer of the Order of the British Empire (OBE), 2010Institute of Physics Presidents medal, 2012Royal Societys Michael Faraday Prize, 2012 In addition to the above awards, Brian Cox has been recognized with a variety of honorary degrees.